Databases of DNA Genomics Discussion

The living organism stores genome databases in long molecules called deoxyribonucleic acids (DNAs) of chromosome and the fragmented section of DNA is called genes. DNA can store only a limited amount of information. For example, a single nucleotide can store 1.8 bits. Within the DNA the nucleotides such as adenine, thymine, guanine, cytosine store the information and act as storage materials.

DNA genomics means studying the DNA gene and its function also detects the abnormalities in the sequence of DNA. Databases of DNA genomics store the information about variations in the genes DNA and it may be locus-specific or general. DNA can store the information in long-chain nucleotides are A, T, G, and C, and these nucleotides are acted as a storage material of DNA. So the DNA turns to a new variety of gathering information and works on information technology. The databases provide already consistently sequenced, synthesized, and accurate copies of information about DNA. Human genome investigations show the impact of trauma that affects the early baby development which is experienced by mothers. This information is already coded in the DNA of successive generations.

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DNA stores the data only in a limited amount. If it stores too much data it gets degraded or breaks. There are some limits for storing a single nucleotide can store 1.8 bits and a single bit represents four base pair of DNA. In humans, each cell contains 6 pg of DNA. In genomic data the alignment data are stored in the Binary Alignment Map (BAM) file is the binary file and the variation is classified as the difference between the real data and reference genome. Virtual Contact File (VCF) stores the result of the data and it is used by the application-specific analysis at once it stores the data. DNA stores the data through its four nucleotides and the important property of DNA is the replication or producing copies. Each double standard DNA helix serves as a pattern for sequence duplication.

DNA databases are otherwise called DNA data bank it contains the full profile and history of DNA. The DNA database investigations are used to identify genetic diseases and in criminology, it detects the genetic fingerprinting or used in the field of genetic genealogy. The collection of DNA databases may be public or private and one biggest example of the database is national DNA databases. The field forensic investigation also needs the help of DNA databases. The link cold hit is used in the forensic field by the way each person’s databases are stored in a DNA profile and during the crime, the sample is matched with the cold hit. A cold hit shows the particular value of a specific person during a crime scene. Without a DNA database, there is no possibility to detect the DNA match.

For genealogical purposes, the DNA profile is very important. In genealogy, the stored DNA profile of genealogical DNA test reports is created by specific databases only for genetic genealogy. Genetic genealogist submitting their results in the specific public genetic genealogy databases that stores genome sequences of DNA called Genbank. Now, GenBank contains a large number of DNA sequences that are provided by the many registered organization for their future purposes and updating the sequence collection to maintain the uniform and comprehensive manner of sequence information. The collections of databases are obtained from the large scale sequencing projects and also individual laboratories providing the information. Different groups are there in Genbank that stores the information the groups are bacterial-BCT, viruses-VRL, primates-PRI, and a few more. If anyone needs the information people can access Genbank. They retrieve it from the retrieval system National Center for Biotechnology Information (NCBI). The “Basic Local Alignment Search Tool (BLAST)” function is also used to identify the sequence and similarity between the two sequences within the Genbank.


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